Under the general increase in allergies in recent decades there has been an increase dell'eczema or pediatric atopic dermatitis (non-contact), as well as asthma and allergic rhinitis. Several studies have indeed shown an association between these forms, for example, recent data indicate that about one third of children who develop atopic eczema of the first four years of age will meet with asthma six years forward. The link is explained by the so-called allergic march, the path of Allergy that is fulfilled in relation to age (prior to the skin and gastrointestinal and respiratory), from which the high risk of passing from eczema to asthma and rhinitis allergic few years later. Less clear is whether there is a link between the insorgenza eczema in childhood distance and persistence of asthma and rhinitis, that is until adolescence or even adults. In fact, a link of this kind seems to be: it highlights an Australian research, the authors know for the first time. The possible therapeutic implications are important, as intuibile.
Association observed up to 44 years
The search has covered more than eight thousand children from a population study began in 1968 when they were seven years, with subsequent observations in 1974 and 2004 in order to verify the possible association between atopic eczema and incidence of childhood asthma in a far to 44 years old. Another objective was to assess whether there were factors in childhood allergic non exhibition that could change an association of this kind. In the sample in total were 520 reported cases of infantile eczema and flexural (on surfaces that bend), plus 301 of the former and 279 of the second. After all the statistical analysis, it appeared a significant association between atopic eczema in childhood accident el'asma both in pre-adolescents (70% more likely) and adolescence (probably more than doubled), both in adult life (63% more likely). Furthermore, atopic eczema in childhood was significantly associated with the persistence of asthma from pediatric to adult, but the evidence of this link has not been executed after the statistical correction for allergic rhinitis.
More aggressive therapeutic approach
Although the majority of children with eczema will not develop asthma in childhood, these findings suggest that the cutaneous form can evolve in the respiratory farther in time, too much. This means that the probability of sooner or later develop asthma as atopic dall'eczema is greater than previously estimated; study the risk of asthma following incident all'eczema child was 12%. The precise mechanism that may explain the link between the two forms is still unclear, involve genetic factors along with other environmental, such a hypothesis is that of an awareness epicutanea consequent exposure of skin damage a potential allergen, followed by migration TH2 cells of the immune memory by the skin of bronchial lymphoid tissue, and subsequent inhalation of sensitizing allergen that causes a response of the airways resulting nell'asma. The study also appeared that the association between asthma and eczema in childhood was more pronounced if there were severe lung infections for the first seven years of age, think about doing a damage to the respiratory tract that increases susceptibility to allergens introduced to dermal. It also confirms that among the childhood allergic disorders, allergic rhinitis is a risk factor most powerful from eczema for the development and persistence of asthma in later age. In any case, considering the pathological burden of asthma, the conclusion to which port the study is that the weight of this progression distance dell'eczema atopic child can be reduced through a more aggressive therapeutic approach against him. The hope of the authors is that to conduct clinical trials to test this strategy.